Vol. 30-31/2021-2022 Nr 60
okładka czasopisma Child Neurology
powiększenie okładki
Journal Info

CHILD NEUROLOGY

Journal of the Polish Society of Child Neurologists

PL ISSN 1230-3690
e-ISSN 2451-1897
DOI 10.20966
Semiannual


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Clinical assessment of treatment of Tourette syndrome in Chinese children with Clonidine transdermal patch


Ocena kliniczna leczenia zespołu Tourette’a w populacji dzieci chińskich za pomocą przezskórnych plastrów klonidyny




Department of Pediatrics, Shaanxi Provincial People’s Hospital

Neurol Dziec 2011; 20, 40: 15-19
Full text PDF Clinical assessment of treatment of Tourette syndrome in Chinese
children with Clonidine transd



ABSTRACT
Objective. To examine and evaluate the clinical efficacy and safety of clonidine transdermal patch in treating Tourette syndrome. (TS). Material and Methods. A total of 130 children aged from 2 to 15 years with TS were randomized into two groups: 71 patients in the treated group were treated with clonidine transdermal patch and 59 in the control group were treated with haloperidol. After 4 weeks of treatment, the clinical efficacy was assessed by the Yale Global Tic Severity Scale(YGTSS). The short-term efficacy and adverse reaction of treatment were assessed at the end of treatment, the longterm efficacy as well as the recurrent rate were evaluated half a year after the end of treatment. Results. The YGTSS score in both groups decreased after 4 weeks of treatment, but the clonidine transdermal patch group showed a higher reduction in the overall tic symptom scores (61.7 ± 7.3%) than that in the haloperidol group. (40.8 ±6.5%; P<0.05). The overall effective rate in Clonidine transdermal patch treatment was 81.7% (effective in 58 patients) and 66.1% to oral haloperidol (effective in 39 patients) (p<0.05). There were no severe adverse events in both groups, but mild side effects (decreased blood pressure and dizziness) were observed in 1 patient in the clonidine transdermal patch group. Mild hypermyotonia, drowsiness or lassitude as side effects occurred in 6 patients in the haloperidol group. Conclusion. Clonidine transdermal patch treatment in TS Chinese children was more effective with lower incidence of adverse reactions and lower recurrent rate as compared with haloperidol group. Clonidine represents a new therapeutic option for the treatment of tic disorder.

Key words: Tourette syndrome, children, treatment, clonidine transdermal patch


STRESZCZENIE
Cel pracy. Zbadanie i ocena skuteczności klinicznej i bezpieczeństwa przeskórnego plastra z klonidyną w leczeniu zespołu Tourette’a (TS). Materiał i metody. Grupa 130 dzieci w wieku od 2 do 15 lat z zespołem Tourette’a została zrandomizowana do dwóch grup: 71 dzieci z badanej grupy było leczonych plastrem przezskórnym z klonidyną, zaś 59 z grupy kontrolnej – haloperidolem. Po czterech tygodniach leczenia skuteczność kliniczna została oceniona za pomocą skali Yale Globar Tic Severity Scale (YGTSS). Skuteczność krótkoterminowa, objawy uboczne leczenia zostały ocenione pod koniec leczenia, zaś skuteczność długoterminową, jak również częstość nawrotów oceniono po pół roku od zakończenia leczenia. Wyniki. Punktacja YGTSS w obu grupach obniżyła się po czterech tygodniach leczenia, ale grupa chorych leczonych klonidyną wykazała większą redukcję tików w ogólnej punktacji tikowej (61,7 ± 7,3%), niż grupa leczonych haloperidolem (40,8 ±6,5%; P<0,05). Średni współczynnik skuteczności przezskórnego plastra z klonidyną wynosił 81,7% (skuteczność u 58 chorych), podczas gdy w przypadku doustnego haloperidolu skuteczność wynosiła 66,1% (skuteczność u 39 chorych) (p<0,05). Nie obserwowano poważnych objawów ubocznych w żadnej z badanych grup. Niewielkie objawy uboczne pod postacią spadku ciśnienia krwi i zawrotów głowy obserwowano u jednego pacjenta leczonego przezskórnie klonidyną. W grupie leczonych haloperidolem obserwowano łagodną miotonię, nudności lub senność u sześciu chorych.

Słowa kluczowe: zespół Tourett’a, dzieci, leczenie, przezskórne plastry klonidyny


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